Biomed Research and Technologies

TOPICAL FORMULATION

Technical Summary Clinical Studies Benefits Patent Status

Biomed Research and Technologies has developed a novel topical formulation that helps the skin restore and rejuvenate its protective barrier layer. The formulation consists of compounds, termed pro-lipids, which skin cells use to produce a variety of lipids that create a protective infrastructure between skin cells. This protective intracellular lipid infrastructure helps prevent moisture loss from the skin, and also helps protect inner skin layers from external threats.

A critical function of the skin is to protect the body from injury, environmental damage, and from moisture loss. This protection is provided by the skin barrier that resides in the stratum corneum. Recent research has revealed that the barrier function of the skin is enabled by unique set of lipids produced by the skin cells in the epidermis. These lipids surround and fill in gaps around the skin cells in the same way that mortar surrounds and holds together bricks in a wall, as illustrated below.

Epidermal cells to the right of the picture are surrounded by skin lipids (shown in blue), whereas cells to the left are devoid of lipids. Epidermal cells without surrounding lipids are susceptible to skin injury, infection and moisture loss. A unique feature of BRT technology is that it replenishes skin lipids.

A healthy skin is able to produce adequate amount of skin lipids. However, the skin’s ability to produce these lipids diminishes with aging, lifestyles, medication and certain skin diseases. For example, smoking, the use of certain medications such as cholesterol-lowering drugs, and diseases such as diabetes adversely affect the production of skin lipids. Certain skin diseases (atopic dermatitis, ichthyosis, and eczema), are also associated with inadequate lipid production. These decreases in lipid production have deleterious consequences on the skin health in general and on the barrier and other functions of the skin in particular. Because adequate lipid production is an important component of good health, there is a need for a technology that can enhance the production of skin’s own lipids. BRT technology replenishes these lipids, with profound implications for skin health.

The Company seeks to license certain market sectors of its lipid regeneration technology to partners with established sales and marketing presence. Opportunities to utilize the Company’s lipid generation technology in other product formats or application are available. Investment inquiries from strategically aligned companies are welcome.

Technical Summary Clinical Studies Benefits Patent Status